Effect of glutamine enriched nutrition support on surgical patients with gastrointestinal tumors: A meta-analysis of randomized controlled trials

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Kang K, Shu X, Zhang Y, Liu X, Zhao J. Effect of glutamine enriched nutrition support on surgical patients with gastrointestinal tumors: A meta-analysis of randomized controlled trials. Chin Med J.2015;128(2):245-251

 

            This study a meta-analysis that looks at the addition of glutamine supplementation in patients with severe traumatic stress or tumor bearing states. The meta-analysis showed that glutamine enriched nutrition support improved immune function, reduced incidence of infectious complications postoperatively, and shortened the length of hospital stays.
            A number of the trials were conducted on patients with post-operative GI cancer patients, but the results seem to be applicable to any severe traumatic stress situation.
            All studies were randomized, but not all studies were blind. For specific dosing of glutamine an investigation of individual studies would have to be done.
            Some of the mechanisms associated with these results are an increase in serum albumin, serum prealbumin, and serum transferring.
Ellsworth

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