Diabetes and Smelling Identification
Lietzau G, Nyström T, C Östenson C, Darsalia V, Patrone C. Type 2 diabetes-induced neuronal pathology in
the piriform cortex of the rat is reversed by the GLP-1 receptor agonist
exendin-4. Oncotarget. 5 Jan 2016. 7(5) 5865- 5876. Retrieved from http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=6823.
Neurodegenerative diseases often present
themselves as difficulty identifying specific odors. This article investigated
the connection between neurological disorders and diabetes through the symptom of
olfactory dysfunction. Looking at type 2
diabetic rats, researchers were trying to figure out the nerve cells
responsible for these smelling difficulties.
What they found were alteration in a group of nerve cells called inter-neurons, located in the area of the brain associated with identifying odor
and coding (the piriform cortex). It was also found that these altercations
could be counteracted pharmacological by clinically used anti-diabetic drugs
(which enhances glucagon-like peptide 1 production).
This
research is useful in preventing neurological diseases from happening in diabetic
patients, such as Alzheimer’s disease.
Also, this article supports the need to screen diabetic patients for
these neurological diseases by performing a smell test. Olfactory dysfunction
is one of the first symptoms of neurological problems, so recognizing this is
these patients is an advantage to health professionals, whom can then
counteract this altercation with anti-diabetic drugs.
DG
Comments
Post a Comment